| Annotated protein: | SPARC-like protein 1 (Matrix glycoprotein Sc1). Gene symbol: SPARCL1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P24054 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ SPARCL1 |
| Ontology domain: | Cellular Component |
| SynGO term: | extracellular matrix of synaptic cleft (GO:0098965) |
| Synapse type(s): | cerebral cortex, glutamatergic |
| Annotated paper: | Lively S, et al. "Localization of the extracellular matrix protein SC1 to synapses in the adult rat brain" Neurochem Res. 2007 Jan;32(1):65-71 PMID:17151913 |
| Figure(s): | Fig. 2B |
| Annotation description: | This study shows that the hevin protein produced by astrocytes is found in the synaptic cleft in the adult rat cerebal cortex. 8/8/2017 Pim - SPRL1_RAT, Hevin, SPARC-like 1, MAST 9 is a known component of the ECM. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Daniela Dieterich (ORCID:0000-0002-9880-1214) Rainer Pielot (ORCID:0000-0002-9681-3318) Karl-Heinz Smalla (ORCID:0000-0002-0269-0311) Eckart Gundelfinger (ORCID:0000-0001-9377-7414) |
| Lab: | Leibniz Institute for Neurobiology (LIN), Institute of Pharmacology and Toxicology, Otto von Guericke University, Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany |
| Additional literature: | This study by means of cell biology that hevin links pre- and postsynaptic cell adhesion molecules, e.g. Neurexin 1 alpha and Neuroligin 1. @ PMID:26771491 |
| SynGO annotation ID: | 1003 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |